Adapalene (CAS 106685-40-9) – Retinoid Acne Treatment API

Adapalene (CAS 106685-40-9) is a high-purity pharmaceutical API, a synthetic retinoid with targeted acne-fighting and anti-inflammatory properties. Its stable molecular structure binds specifically to retinoid nuclear receptors without interacting with cytoplasmic receptors, normalizing follicular keratinization to prevent pore clogging and reduce microcomedone formation. Unlike traditional retinoids, it is more tolerable, less irritating, and stable under light and oxygen—maintaining efficacy without rapid degradation.

As a white or off-white powder compatible with topical formulations, it is ideal for gels, creams, and lotions—the primary clinical dosage forms. It meets the core needs of dermatological drug manufacturers, acne care product developers, and clinical supply chains. Widely used for mild to moderate acne vulgaris on the face, chest, and back, it addresses blackheads, whiteheads, papules, and pustules while improving skin texture. Produced under strict GMP standards, each batch undergoes rigorous purity (≥98%) and stability testing to meet international pharmacopoeia requirements, ensuring reliable clinical performance for acne management.