PE-22-28 (CAS 1801959-12-5) – Neuroprotective Neuropeptide API

PE-22-28 (CAS 1801959-12-5) is a high-purity neuroprotective neuropeptide API, featuring ≥98% purity (HPLC-verified) and a 7-amino-acid sequence (molecular weight: ~773.89 Da). As a potent TREK-1 potassium channel inhibitor (IC50=0.12 nM), it blocks neuronal hyperpolarization to reduce apoptotic cell death—its core mechanism for neuroprotection.

This lyophilized powder dissolves easily in aqueous solvents and maintains stable activity under ≤6℃ storage. It is widely used in preclinical research: it alleviates stroke-induced motor/cognitive defects, promotes hippocampal neurogenesis, and supports antidepressant mechanism studies. For neuroscience R&D teams, its high potency and dual neuroprotective-antidepressant properties make it a reliable raw material for neurological disorder and mood regulation research.