PNC 27 (CAS 1159861-00-3) – Pnc 27 Peptide 

PNC 27 (CAS 1159861-00-3) is a high-purity anticancer peptide API with ≥98% purity (HPLC-verified), featuring a 32-amino acid structure (molecular weight: ~4031.7 Da). As a chimeric p53-penetratin peptide, it binds specifically to HDM-2 proteins expressed on cancer cell membranes, inducing selective transmembrane pore formation that leads to cancer cell lysis while sparing normal cells.

This lyophilized peptide demonstrates exceptional target specificity and membrane-disrupting activity, making it ideal for preclinical cancer research. Studies have shown its effectiveness against various solid tumors (pancreatic, breast, colon) and hematological malignancies. Its unique dual mechanism—specific receptor binding followed by physical membrane disruption—offers researchers a powerful tool to explore cancer cell death pathways and develop novel targeted cancer therapies.